Romosozumab side effects
Dr Nirmal Dr Renu.....pl tell me whether there is any side effect(especially decrese appetite ) after Inj Romosozumab for severe osteoporosis?pl reply.
Decreased appetite is not a typical side effect of romosozumab. The most common adverse events are injection‑site pain or redness, joint or muscle aches, headache, and occasionally mild hypocalcemia, especially when calcium or vitamin D intake is insufficient. Rare but serious risks include a possible small increase in heart‑attack or stroke risk (the drug is avoided in patients with a recent myocardial infarction or stroke), allergic reactions, and very rare osteonecrosis of the jaw and atypical femur fractures (mainly after prolonged anti‑resorptive therapy). Patients should ensure adequate calcium (≈1,000–1,200 mg per day) and vitamin D (800–1,000 IU per day, aiming for 25‑OH‑D ≥30 ng/mL) before and during treatment to reduce hypocalcemia. If appetite loss does occur, look for other causes and check serum calcium and vitamin D levels. Seek urgent medical attention for new chest pain, shortness of breath, neurologic symptoms, or persistent appetite loss.