Nattokinase efficacy and statin selection for South Asians
Been reading about Nattokinase for reducing LDL. Are any of these claims scientifically tested? What statins are better suited for south asians that cause minimal side effects?
There is some data on this from SMALL studies demonstrating improved lipid profiles, and also other benefits such as mild BP reductions and also antithrombotic activity. However, well done, large randomized controlled trials demonstrating clear efficacy are lacking. A few take home messages: 1) Data is not clear enough to recommend regular use 2) It may have effects on the coagulation pathways resulting in increased bleeding risk 3) It may interact with medications, particularly blood thinners, with potential resulting side effects. Overall: wait for more data On the second part of the question: STATINS AND SOUTH ASIANS: 1. Statins, particularly Rosuvastatin, may actually work somewhat MORE in South Asians. So it is recommended to start LOW in South asians (recommended starting dose for Rosu is 5 mg in South Asians) 2. STATINS SOMEWHAT LESS LIKELY TO CAUSE NUISANCE SIDE EFFECTS SUCH AS MUSCLE ACHES: Rosuvastatin (Most effective and potent in lowering LDL cholesterol) and Pravastatin (less effective but also less chances of muscle side effects)